Process for preparing iodothyronines and iodothyroacetic acids b

Details Process for preparing iodothyronines and iodothyroacetic acids b Process for preparing iodothyronines and iodothyroacetic acids b

1983-04-28

1984-12-25

Tung, T.

Chemistry: electrical and wave energy

Processes and products

204 59R, 204 73R, C25B 300, C07C10172

Patent

active

044902212

ABSTRACT:
The invention relates to a process for preparing tri-iodo-, di-iodo- and mono-iodothyronines and tri-iodo, di-iodo and mono-iodothyroacetic acids, respectively from thyronine, triiodo or diiodothyro- nine and tetra-, tri- or diiodothyroacetic acid, by electrochemical reduction at controlled potential, in an aqueous medium rendered alkaline by the addition in particular of a tetraalkylammonium hydroxide, whereby either the iodine in 5 position or the iodine in 3 position is selectively reduced, depending on the potential at which operation is carried out, and which is determined previously by plotting a polarograph of the starting substance.

REFERENCES:
Synthesis of Thyroid Hormone Metabolites by Photolysis of Thyroxine and Thyroxine Analogs in the Near UV, pp. 1492-1496, Mar. 1982, vol. 79, Walt and Cahumann, Proc. Natl. Acad. Sci., USA.
Synthesis of .sup.125 I-reverse T.sub.3 using a low and a high 3,3'-di-iodothyronine/.sup.125 I ratio, pp. 773-776, vol. 41 (8), 1981, Scandinavian Jour. Clinical and Lab. Investigation.
Preparation of High Specific Activity Labelled 3,3',5'-Triiodothyronine Reverse T-3, pp. 174-176, vol. 5 (4-5) 1978, International Journal of Nuclear Medicine and Biology.
Saishin Igaku, vol. 31 (5), 1976, pp. 893-897.

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