Process for preparing intermediates for the synthesis of antifun

Details Process for preparing intermediates for the synthesis of antifun Process for preparing intermediates for the synthesis of antifun

1996-12-12

1998-05-26

Geist, Gary

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

C07C 6700, C07C 6712

Patent

active

057568308

ABSTRACT:
A process for producing a crystalline chiral hydroxy ester of the formula: ##STR1## is disclosed. The process comprises reacting a diol of the formula: ##STR2## with an effective amount of isobutryic anhydride and an effective amount of a lipase enzyme in an effective amount of acetonitrile, said reaction being conducted at a low temperature, and wherein X.sup.1 and X.sup.2 are each independently selected from F or Cl.

REFERENCES:
patent: 3923865 (1975-12-01), Nelson
patent: 5403937 (1995-04-01), Saksena et al.
patent: 5442093 (1995-08-01), Sudhakar
Saksena et al. (1995) Tetrahedron Letters, 36(11) pp. 1787-1790.
Martinelle et al. (1995) Biochimica et Biophysica Acta, 1251, pp. 191-197.

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