Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Recombinant or stably-transformed bacterium encoding one or...
Patent
1973-03-20
1976-05-18
Waddell, Frederick E.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Recombinant or stably-transformed bacterium encoding one or...
A61K 4500
Patent
active
039580148
ABSTRACT:
An injectable fluorocarbon emulsion capable of carrying oxygen, which can be used as artificial blood and organ perfusate, is prepared by emulsifying a fluorocarbon, having an ability to dissolve at least 30 V/V % of oxygen under a 100% oxygen atmosphere at an atmospheric pressure, in an aqueous salt solution with a surfactant, centrifuging the resulting aqueous emulsion thereby to reduce the fluorocarbon particles in the emulsion in size to particle sizes of the order of about 0.05 to 0.25 .mu., and then sterilizing the thus obtained emulsion under rotation. The resulting fluorocarbon emulsion can be used as an emergency blood substitute for transfusion.
REFERENCES:
science Vol. 152, 1755-1756 (1966).
Symposium on Inert Liquids for Biological Oxygen Transport-Atlantic City, N.J., Apr. 13, 1969 - Fed. Pro. 1970, pp. 1695-1697, 1758-1763.
Odaka Yohei
Suyama Tadakazu
Watanabe Ryozo
Yokoyama Kazumasa
Tanabe Seiyaku Co. Ltd.
The Green Cross Corporation
Waddell Frederick E.
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