Process for preparing imidazole derivative

Details Process for preparing imidazole derivative Process for preparing imidazole derivative

1996-12-18

1999-01-12

Morris, Patricia L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

5483031, C07D49504, C07D49304

Patent

active

058592601

ABSTRACT:
An imidazole derivative of the general formula (1): ##STR1## wherein R.sup.1 and R.sup.2 are each a hydrogen atom or an alkyl, aryl, acyl or aralkyl group, X and Y are each an oxygen or sulfur atom, and Z is a substituted alkyl group is prepared by reducing a thienoimidazole carboxylic acid of the general formula (2): ##STR2## in an alcoholic solvent using a palladium catalyst, adding an adsorbent and an ion exchange resin, chelate resin or polymeric flocculating agent to the reaction mixture, and removing the spent catalyst from the reaction mixture.

REFERENCES:
patent: 5498721 (1996-03-01), Mizuno et al.
Acc. No. #95-330776, Japio, "Production of Biotin, etc" Dec. 1995.

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