Process for preparing ibuprofen and its alkyl esters

Details Process for preparing ibuprofen and its alkyl esters Process for preparing ibuprofen and its alkyl esters

1989-12-18

1991-02-05

Killos, Paul J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

560105, C07C 5114

Patent

active

049906585

ABSTRACT:
A new process for preparing ibuprofen or its alkyl esters is provided. A 1-halo-1-(4-isobutylphenyl)ethane is reacted with carbon monoxide in the presence of water or an alcohol at a temperature between about 10.degree. C. and about 200.degree. C. An excess of several moles of water or alcohol is preferred. An acid such as hydrochloric acid may also be added. As catalyst, a palladium compound and at least one acid-stable ligand are present; however an excess of ligand over palladium is advantageous.

REFERENCES:
patent: 4034004 (1977-07-01), Cassar et al.
patent: 4439618 (1984-03-01), Cometti et al.
patent: 4536595 (1985-08-01), Gardano et al.
patent: 4537970 (1985-08-01), Foa et al.
patent: 4654436 (1987-03-01), Lane et al.
patent: 4713484 (1987-12-01), Epstein

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