Process for preparing hydroxybenzocyclobutenes

Details Process for preparing hydroxybenzocyclobutenes Process for preparing hydroxybenzocyclobutenes

1992-07-30

1993-07-13

Lone, Werren B.

Organic compounds -- part of the class 532-570 series

Organic compounds

Oxygen containing

568731, 568732, 568796, C07C 3917, C07C 3702

Patent

active

052275361

ABSTRACT:
A process for preparing a 3- or 4-hydroxybenzocyclobutene comprises reacting a 3- or 4-halogenzocyclobutene reactant with an alkali metal hydroxide by heating in an aqueous alcohol medium at a temperature from about 50.degree. C. to a temperature at which dimerization or oligomerization of a benzocyclobutene reactant or product is a significant side reaction, in the presence of a metal-containing catalyst, for a time sufficient to convert the halobenzocyclobutene reactant to the hydroxybenzocyclobutene product.

REFERENCES:
patent: 1882824 (1932-10-01), Hale
patent: 2028065 (1930-01-01), Hale
patent: 2137587 (1938-11-01), Poffenberger
patent: 2138609 (1938-11-01), Meyer
patent: 4001340 (1977-01-01), Smith et al.
patent: 4540763 (1985-09-01), Kirchhoff
patent: 4570011 (1986-02-01), So
patent: 4684749 (1987-08-01), Paparatto
patent: 4783514 (1988-11-01), Kirchhoff et al.
patent: 4822930 (1989-04-01), Liu
patent: 4853487 (1989-08-01), Nonn
patent: 4891452 (1990-01-01), Nonn et al.
patent: 4999449 (1991-03-01), Kirchhoff
Chem. Ber., vol. 93 (1960), pp. 1774-1781, L. Horner et al. Zur elektgrophilen substitution des benzocyclobutens.
J. Org. Chem., vol. 40 (1975), pp. 3649-3650, T. Cohen et al., Copper(I)-Induced Reductive Dehalogenation, Hydrolysis, or Coupling of Some Aryl & Vinyl Halides at Room Temperature.
Tetrahedron, vol. 40 (1984), pp. 1433-1456, J. Lindley; Copper Assisted Nucleophilic Substitution of Aryl Halogen.
Tetrahedron, vol. 45 (1989) pp. 5565-5576, Henk L. Aalten et al.; The Copper Catalysed Reaction of Sodium Methoxidde with Aryl Bromides.
J. Chem. Soc. (C), (1969), pp. 312-315, R. G. R. Bacon et al.,; Metal Ions and Complexes in Organic Reactions.
Russ Chem Rev., vol. 43 pp. 679-689, A. A. Moroz et al; Ullmann Ether Condensation.
J. Org. Chem., vol. 29 (1964), pp. 3624-3626, H. Weingarten Mech. of Ullman Condensation.
J. Org. Chem., vol. 29 (1964), pp. 977-978, H. Weingarten Ullman Condensation.
J. Org., Chem. vol. 32 (1967), pp. 2501-2505, A. L. Williams et al.; Solvent-assisted Ullmann, Ether Synthesis. Reactions of Dihydric Phenols.
Australian J. of Chem., (1975), after p. 1741, W. D. Crow et al.
Tetrahedron Letters, vol. 22 (1977) pp. 1867-1870 J. M. Riemann et al.

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