Process for preparing hydratropic acids and esters thereof, from

Details Process for preparing hydratropic acids and esters thereof, from Process for preparing hydratropic acids and esters thereof, from

1985-05-03

1987-05-19

Killos, Paul J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

562465, 562496, 560102, 560105, 560 59, 560 55, C07C 6300

Patent

active

046670564

ABSTRACT:
A process for preparing hydratropic acids and the esters thereof, of formula Ar--CH(CH.sub.3)--COOR where R=H or lower alkyl and Ar=phenyl possibly substituted. This process consists in reacting on the propiophenones of formula ArCOCH.sub.2 CH.sub.3, a chlorinating or brominating agent, an alcohol R'OH where R'=lower alkyl, an orthoester R.sub.1 --C(OR').sub.3 wherein R.sub.1 =H or lower alkyl, and metal zinc; then possibly hydrolyzing the esters obtained.
With this process can be prepared hydratropic acids known for their anti-inflammatory activity.

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