Process for preparing hybridoma cells which produce tumor-specif

Details Process for preparing hybridoma cells which produce tumor-specif Process for preparing hybridoma cells which produce tumor-specif

1988-09-14

1990-01-09

Moskowitz, Margaret

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Blood proteins or globulins, e.g., proteoglycans, platelet...

43524027, 435 7021, 4351722, 424 858, 530806, 530808, 530828, 935105, C07K 1514, A61K 39395, C12N 1500

Patent

active

048929344

ABSTRACT:
High-yielding hybridoma cell lines which secrete monoclonal antibodies capable of binding to tumor cells of one or more types, but not normal cells can be obtained more readily by fusing myeloma cells with antibody-forming cells isolated from an animal immunized with tumor antigens, which has previously been made immunological tolerant to normal cell antigens, comprising the total antigens, or at least a proportion of the total antigens, of the normal cells corresponding to the tumor cells chosen as the source of immunizing antigens.

REFERENCES:
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patent: 4513088 (1985-04-01), Levy
patent: 4666845 (1987-05-01), Mattes
Middleton, S. et al, Fed. Proc. 39:3464 (1980).
Sharpe, R. J. et al, Transplantation Proceedings, 17(6): 2757-2759 (12-1985).
Golumbeski, G. S. et al, Analytical Biochemistry, 154: 373-381 (1986).
Hanai, N. et al, Cancer Research, 46: 4438-4443 (9-1986).
Sharpe, R. J. et al, Med. Hypotheses 17(3): 265-270 (1985), cited in Biosis Abstract 85:407403.
Kohler and Milstein, Nature, 256, pp. 495-497 (1975).

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