Process for preparing (+)-homopilopic acid

Details Process for preparing (+)-homopilopic acid Process for preparing (+)-homopilopic acid

1990-11-16

1993-01-26

Lilling, Herbert J.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing heterocyclic carbon compound having only o, n, s,...

435118, 435197, 435198, 435280, 435822, 435839, 435840, 435939, C12P 1704, C12N 918, C12N 920, C12R 1845

Patent

active

051821982

ABSTRACT:
A process for preparing (+)-homopilopic acid and the salts thereof which comprises hydrolyzing a mixture of (+)-homopilopic acid ester of the general formula (I): ##STR1## wherein R.sub.1 denotes straight or branched C.sub.1 -C.sub.10 hydrocarbon, and (-)-homopilopic acid ester of the general formula (II): ##STR2## wherein R.sub.2 denotes straight or branched C.sub.1 -C.sub.10 hydrocarbon, in the presence of a microorganism belonging to the genus Arthrobacter, Aspergillus, Escherichia, Cunninghamella, Xanthomonas, Candida, Pseudomonas, Serratia, Cellulomonas, Nocardia, Bacillus, Brevibacterium, Flavobacterium, Mycobacterium, Rhizomucor, Rhodotorula or Rhodococcus, or a treated matter thereof.

REFERENCES:
CA.89:24125h Zvonkova et al., "Homopilopic Acid" USSR 589,243 Apr. 1976 vol. 89 (1978).
CA78:43245m Zav'yalov et al., "Homoisopilopic Acid" USSR 352,892 Sep. 1972.
CA 99886x DeGraw Tetrahed Lts. 1972 '28 (4)967-72 vol. 76 (1972).
CA 51497z Chumachenko et al., vol. 69 (1968) SSSR 1968 178(6) 1352-5.
J. I. DeGraw et al., J. Pharm. Sci., 64:1700-1701 (1975).
DeGraw, Tetrahedron, vol. 28, 967-972 (1972).

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