Process for preparing HMG-CoA reductase inhibitors with a 3,5-di

Details Process for preparing HMG-CoA reductase inhibitors with a 3,5-di Process for preparing HMG-CoA reductase inhibitors with a 3,5-di

1985-04-25

1987-02-24

Lone, Werren B.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

C07C 69767

Patent

active

046458549

ABSTRACT:
A stereoselective process for the preparation of antihypercholesterolemic agents of the HMG-CoA reductase inhibitor type comprises treatment of an intermediate .beta.-hydroxyketone with a trialkylborane and sodium borohydride at low temperatures.

REFERENCES:
patent: 4255444 (1980-09-01), Schmitt et al.
patent: 4375475 (1983-03-01), Willard
Hsu et al, "J. Amer. Chem. Soc.", vol. 105, pp. 593-601 (1983).
Narasaka et al, "Chemistry Letters" (1980), 1415-1418.

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