Organic compounds -- part of the class 532-570 series – Organic compounds – Heavy metal containing
Patent
1989-10-25
1991-04-30
Prescott, Arthur C.
Organic compounds -- part of the class 532-570 series
Organic compounds
Heavy metal containing
556113, 556116, C07F 108
Patent
active
050119583
ABSTRACT:
This invention encompasses a process for preparing higher order cuprate complexes which contain a carbanion for the formation of carbon to carbon bonds in reactions such as epoxide addition. The complex is formed by reacting a first cuprate complex with a stannane such that the carbanion to be used to form carbon to carbon bonds is transferred from the stannane to the first cuprate complex to form a different higher order cuprate complex. This process permits the in situ preparation of a higher order cuprate complex having the carbanion desired to be used in a synthetic reaction. Higher order cuprate complexes derived from the reaction of a cuprate complex with 1,2-bis-tri-n-butylstannyl ethylene are particularly useful for the addition to epoxides to form vinyl tin intermediates useful for preparing omega side chains of prostaglandins.
REFERENCES:
patent: Re30287 (1980-05-01), Marx et al.
patent: 3734963 (1973-05-01), Langer, Jr. et al.
patent: 3965143 (1976-06-01), Collins et al.
patent: 4271314 (1981-06-01), Collins et al.
patent: 4287190 (1981-09-01), Boettcher et al.
patent: 4322543 (1982-03-01), Collins et al.
patent: 4499296 (1985-02-01), Collins et al.
patent: 4529812 (1985-07-01), Collins et al.
patent: 4578505 (1986-03-01), Collins et al.
patent: 4777275 (1988-10-01), Campbell et al.
Lipshutz, "Applications of Higher Order Mixes Organocuprates to Organic Synthesis", Synthesis, 4, p. 325, (1987).
Bindra and Bindra, "Prostaglandin Synthesis", Academic Press, Inc., N.Y., Chapter 7, pp. 99-108.
Collins, J. Med. Chem., 29, 437, (1986).
Corey et al., J.A.C.S., 94, 7210-11, (1972).
Lipshutz et al., Tetrahedron, vol. 40, No. 24, pp. 5005+, 1984.
Babiak Kevin A.
Behling James R.
Campbell Arthur L.
Ng John S.
G. D. Searle & Co.
Matukaitis Paul D.
Prescott Arthur C.
Williams Roger A.
LandOfFree
Process for preparing higher order cuprate complexes does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Process for preparing higher order cuprate complexes, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for preparing higher order cuprate complexes will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-641426