Process for preparing hexahydropyridazine-3-carboxylic acid...

Organic compounds -- part of the class 532-570 series – Organic compounds – Four or more ring nitrogens in the bicyclo ring system

Reexamination Certificate

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C564S464000

Reexamination Certificate

active

07132535

ABSTRACT:
According to the process of the invention, the hexahydropyridazine-3-carboxylic acid derivatives are prepared by reacting a compound of formula (II)with a compound of formula (III)in the presence of a base with a pK of greater than or equal to 8.5, in a ketone organic solvent, to obtain an intermediate compound that is not isolated and that is treated with a basic aqueous medium.By means of this process, the derivatives are obtained more quickly and more economically.

REFERENCES:
patent: 4988813 (1991-01-01), Taylor et al.
patent: 6632942 (2003-10-01), Robidoux et al.
patent: 9955724 (1999-11-01), None
Bioorganic & Medicinal Chemistry 10, (2002) 953-961 CYCLIC . . . RH-5849.
J. Org. Chem, vol. 24, 1959, pp. 724-725 Alkylation of Some Diacyclhydrazines, Hinman et al.

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