Process for preparing hexahydro-11 (eq)-CH.sub.2 CH.sub.2 COR.su

Details Process for preparing hexahydro-11 (eq)-CH.sub.2 CH.sub.2 COR.su Process for preparing hexahydro-11 (eq)-CH.sub.2 CH.sub.2 COR.su

1977-07-25

1978-10-10

Jiles, Henry R.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260287B, C07D22126

Patent

active

041196287

ABSTRACT:
Lower-alkyl 1-R.sub.1 -3-R.sub.5 CO-4a.alpha.-R.sub.3 -5.alpha.-R.sub.4 -6-R.sub.2 "-7-R.sub.2 -8-R.sub.2 '-9-R.sub.2 '"-1,2,3,4,4a,5,10,10a-octahydro-2,5-methanobenzo[g]-quinoline-3-carboxyla tes, useful as intermediates for the preparation of 3-R.sub.1 -6(eq)-R.sub.4 -7-R.sub.2 "-8-R.sub.2 -9-R.sub.2 '-10-R.sub.2 '"-11(ax)-R.sub.3 -1,2,3,4,5,6,-hexahydro-11(eq)--CH.sub.2 CH.sub.2 COR.sub.5 --2,6-methano-3-benzazocines, useful as analgesics and narcotic antagonists, are prepared by acylation of an appropriate lower-alkyl 1-R.sub.1 -4a.alpha.-R.sub.3 -5.alpha.-R.sub.4 -6-R.sub.2 "-7-R.sub.2 -8-R.sub.2 '-9-R.sub.2 '"-1,2,3,4,4a,5,10,10a-octahydro-2,5-methanobenzo[g]quinoline-3-carboxylat e or carboxylation of an appropriate 1-R.sub.1 -3-COR.sub.5 "-4a.alpha.-R.sub.3 -5.alpha.-R.sub.4 -6-R.sub.2 "-7-R.sub.2 -8-R.sub.2 '-9-R.sub.2 '"-1,2,3,4,4a,5,10,10a-octahydro-2,5-methanobenzo[g]quinoline.

REFERENCES:
house, H.O., Modern Synthetic Reactions, 2nd Edition, W. A. Benjamin, Menlo Park, Cal. 1972, pp. 514-515.
Fieser, L. and Fieser, M., Reagents for Organic Synthesis, vol. 1, John Wiley and Sons, NY, 1967, p. 1231.
Fieser, L. and Fieser, M., Reagents for Organic Synthesis, vol. 3, John Wiley and Sons, N.Y., 1972, p. 300.

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