Process for preparing hepatitis B surface antigen containing par

Details Process for preparing hepatitis B surface antigen containing par Process for preparing hepatitis B surface antigen containing par

1985-04-01

1987-09-22

Kight, John

Drug, bio-affecting and body treating compositions

Lymphokine

435236, 530427, 530806, 530826, A61K 3516, A61K 3929

Patent

active

046954546

ABSTRACT:
There is disclosed a process for producing a proteinaceous mass containing particles of HBsAg in a morphological form not found in nature while inactivating any live virus contained therein. The process comprises subjecting a concentrated mass thereof free of protein diluent or a stabilizer to a heat inactivation by heating the same while in a concentration of at least 1 mg/ml at a temperature of 101.degree. to 105.degree. C. for 1 to 5 minutes and thereafter cooling the so heated particles.

REFERENCES:
patent: 3636191 (1969-10-01), Blumberg et al.
patent: 4424206 (1984-01-01), Ohmura et al.
patent: 4438098 (1984-03-01), Tabor et al.
patent: 4440679 (1984-04-01), Fernandes et al.
patent: 4565697 (1986-01-01), Ohmura et al.
Alfred M. Prince, Pro. Nat. Acad. Sci. (U.S.), 60:814-821 1968.
A. M. Prince, J. Vnek & B. Brotman, "An Affordable Multideterminant Plasma-Derived Hepatitis B. Virus Vaccine", 1984, IARC Scientific Publications, No. 63, pp. 355-372.

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