Process for preparing hepatitis A (HAV) antigens and vaccines

Details Process for preparing hepatitis A (HAV) antigens and vaccines Process for preparing hepatitis A (HAV) antigens and vaccines

1993-10-13

1998-03-24

Hutzell, Paula K.

Chemistry: molecular biology and microbiology

Virus or bacteriophage, except for viral vector or...

435239, 435 89, 435948, 4242261, 4241891, C12N 700, C12N 702, A61K 3929

Patent

active

057311870

ABSTRACT:
Process for preparing hepatitis A (HAV) antigens and vaccines.
The HAV virus is multiplied on competent cells, the infected cells are lysed, the supernatant is recovered and the purification is carried out by a chromatographic procedure on an anion-exchange support and a gel filtration procedure, the purification procedures being carried out in the presence of a detergent, and the chromatographic procedure being carried out under conditions which retain the virions or viral capsids, which are then eluted.

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Welling-Wester et al J. Chromatography 646:37-44, 1993.
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D'Hundt, E. Vaccine 10, Suppl 1 548-553, 1992.
Alligen H. American Laboratory, Oct. 1975 (7 pages).
England et al, Methods in Enzymology 182:285-300, 1990.

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