Process for preparing haptoglobin aqueous solution using strong

Details Process for preparing haptoglobin aqueous solution using strong Process for preparing haptoglobin aqueous solution using strong

1977-04-19

1979-01-30

Rosen, Sam

Drug, bio-affecting and body treating compositions

Immunoglobulin, antiserum, antibody, or antibody fragment,...

Reduced antigenicity, reduced ability to bind complement, or...

260112B, A61K 3704, A61K 3706, C07G 700

Patent

active

041373073

ABSTRACT:
An aqueous solution of haptoglobin is obtained by subjecting an aqueous solution of .alpha. and .beta.-globulin fractions of human blood plasma to further fractionation by use of ammonium sulfate, collecting fractions precipitated at a concentration between 30% and 40% saturation of ammonium sulfate, contacting a reconstituted aqueous solution of the collected fractions with an anion exchanger to adsorb haptoglobin on said anion exchanger, selectively eluting the haptoglobin from the anion exchanger, and then concentrating the resulting aqueous eluate solution. The aqueous solution of haptoglobin is subjected to heat treatment in the presence of a selected stabilizing agent for inactivating hepatitis B virus at an optional step of the process.
The thus obtained aqueous solution of haptoglobin has less than 10% hypotensive activity, highly stable during storage, and free from the risk of hepatitis B virus infection. This haptoglobin preparation is used for prevention and treatment of renal disorders caused by hemolysis.

REFERENCES:
betlach et al. -- Chem. Abst., vol. 77, (1972), p. 85167x.
Oh et al. -- Chem. Abst., vol. 76, (1972), p. 82426z.
Betlach et al. -- Annals of Biochemistry, vol. 49, No. 1, (1972), pp. 103-108.

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