Process for preparing grignard reagents in diethylene glycol dib

Details Process for preparing grignard reagents in diethylene glycol dib Process for preparing grignard reagents in diethylene glycol dib

1993-07-02

1994-10-25

Dees, Jose' G.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

C07F 302

Patent

active

053586700

ABSTRACT:
This invention relates to an alkyl Grignard reagents in diethylene glycol dibutyl ether. The invention also relates to a novel method for preparing Grignard reagents comprising reacting an alkyl halide with magnesium metal in the presence of diethylene glycol dibutyl ether. Grignard reagents prepared in the presence of diethylene glycol dibutyl ether have improved yields and stability, including storage stability, at room temperature. The Grignard reagents are prepared without the use of a low boiling and/or flammable stabilizing agents such as benzene, toluene, tetrahydrofuran, and diethyl ether.

REFERENCES:
patent: 2552676 (1951-05-01), Hill
patent: 2838508 (1958-06-01), Ramsden
patent: 3758620 (1973-09-01), Vit
A Novel, Continuous High-Yield Synthesis Of Grignard Reagents J. R. Jennings, Journal of Organometallic Chemistry 1987 vol. 325 pp. 25-29.
An Improved Preparation of a Grignard Reagent, T. S. Eckert, Journal of Chemical Education, 1987 vol. 64 p. 179.
Preparation Of Grignard Reagents By Continuous Process, Thust et al, Chemical Abstracts, vol. 110 1989, p. 740.
Method For The Preparation Of di-Grignard Reagent Phenylenebis (magnesium chloride), Wang et al., Chemical Abstracts, vol. 114, 1991 p. 837.
Preparation Of Pyridyl Grignard Reagents And Cross Coupling Reactions With Sulfoxides Bearing Azaeheterocycles, Furukawa et al, Tetrahedron Letters, vol. 28 1987 pp. 5845-5848.
Mechanical Activation Of Magnesium Turnings For The Preparation Of Reactive Grignard Reagents, Baker et al., J. Org. Chem. 1991, 56, pp. 698-703.
Preparation of Grignard-type Organometallic Compounds, Z. Wirpsza, Chemical Abstracts, vol. 110, 1989, p. 13.

Affiliated with

Also associated with

Rating

Process for preparing grignard reagents in diethylene glycol dib does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for preparing grignard reagents in diethylene glycol dib, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for preparing grignard reagents in diethylene glycol dib will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-133314