Process for preparing granulate containing poorly compressible m

Details Process for preparing granulate containing poorly compressible m Process for preparing granulate containing poorly compressible m

1983-08-08

1985-12-31

Thurlow, Jeffery

Plastic and nonmetallic article shaping or treating: processes

Forming articles by uniting randomly associated particles

Agitating to form larger particles

264122, 264128, 514629, 514562, C09C 156

Patent

active

045620245

ABSTRACT:
An improved wet granulation process for preparing compressed tablets, particularly those containing a poorly compressible medicament, e.g., paracetamol and derivatives thereof, the improvement which comprises homogenizing part only of particulate solid material including active matter and tabletting aids with at least 90% by weight of a predetermined quantity of granulating fluid, so as to form a substantially homogenous slurry wherein the percentage of weight of solids, both dissolved and undissolved, in the slurry is at least about 25% w/w; and then moistening the remaining part of the particulate solid material in the manner of wet granulation but with the slurry resultant from above (and thereafter with the balance of the granulating fluid, if any) so as thus to form a desired substantially uniform, moist, coherent, non-pasty mass ready for granulation. Said mass is then granulated and dried, and the dried granules compressed and compacted into tablets.

REFERENCES:
patent: 2877159 (1959-03-01), Lachman et al.
patent: 3084104 (1963-04-01), Tuerck et al.
patent: 3406426 (1968-10-01), Pobst, Jr. et al.
patent: 3671633 (1972-06-01), Sleth et al.
patent: 3705019 (1972-12-01), Mesiah et al.
patent: 3789119 (1974-01-01), Fusari et al.
patent: 3860526 (1975-01-01), Corbett
patent: 3987138 (1976-10-01), Hege
patent: 4132753 (1979-01-01), Blichare et al.
patent: 4322449 (1982-03-01), Voss et al.

Affiliated with

Also associated with

Rating

Process for preparing granulate containing poorly compressible m does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for preparing granulate containing poorly compressible m, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for preparing granulate containing poorly compressible m will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1023771