Process for preparing glyoxylic acid/dialkyl aminomethylphosphon

Details Process for preparing glyoxylic acid/dialkyl aminomethylphosphon Process for preparing glyoxylic acid/dialkyl aminomethylphosphon

1995-02-08

1996-09-24

Rollins, John W.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing oxygen-containing organic compound

435128, 435106, 562 17, C12P 740, C12P 742, C12P 1300, C07F 922

Patent

active

055590209

ABSTRACT:
The invention provides a process for producing mixtures of glyoxylate and a dialkyl aminomethylphosphonate and the subsequent production of N-(phosphonomethyl)glycine, also known as glyphosate. The process comprises preparing in situ a mixture of glyoxylate and a dialkyl aminomethylphosphonate (DEAMPA) by enzymatically reacting glycolic acid (glycolate) and oxygen in an aqueous solution in the presence of a dialkyl aminomethylphosphonate and catalysts consisting of glycolate oxidase and catalase. The resulting mixture can be hydrogenated and then subjected to hydrolysis to produce N-(phosphonomethyl)glycine, a post-emergent phytotoxicant and herbicide.

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