Process for preparing glycosylated analogs of camptothecin

Details Process for preparing glycosylated analogs of camptothecin Process for preparing glycosylated analogs of camptothecin

1997-06-16

1999-08-03

Peselev, Elli

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 41, 536 172, 536 179, 536 181, 536 185, C07H 100

Patent

active

059327090

ABSTRACT:
The present invention relates to chemotherapeutic agents, and more particularly, to novel analogs of camptothecin. The camptothecin analogs display increased solubility through the hydrophilicity of added non-ionic sugar substituents. In accordance with the present invention, a member from the class of novel camptothecin analogs is to be delivered in vivo as a chemotherapeutic agent to fight cancer growth in the body.

REFERENCES:
patent: 5446047 (1995-08-01), Danislefsky et al.

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