Process for preparing glial mitogenic factors

Details Process for preparing glial mitogenic factors Process for preparing glial mitogenic factors

1995-06-06

1997-02-25

Schain, Howard F.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Separation or purification

530413, 530417, 530414, 530415, C07K 116, C07K 118, C07K 122, C07K 136

Patent

active

056060327

ABSTRACT:
The invention involves the purification of various glial mitogenic factors. In one aspect of the invention, vertebrate brain material is extracted, and the extract is then subjected to chromatographic separation. The glial mitogenic factors which can be obtained include a basic polypeptide with a molecular weight of from about 30 to about 36 kD, by reference to SDS-PAGE, and a second basic polypeptide factor which is from about 55 to about 63 kD as determined by SDS-page.

REFERENCES:
Brockes et al, J. Neuroscience 4 (1984), 75-83.
Brockes et al J. Biol. Chem. 255(1980) 8374-8377.
Benveniste et al (PNAS 82 (1985), 3930-3934).
Holmes et al. Science (1992) 256:1205.
Davis et al. J. Cell. Biol., 110(1990), 1353-1360.

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