Process for preparing florfenicol

Details Process for preparing florfenicol Process for preparing florfenicol

2006-10-24

2006-10-24

Shameem, Golam M. M. (Department: 1626)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C558S061000

Reexamination Certificate

active

07126005

ABSTRACT:
The present invention is directed to a new process of preparing highly pure Florfenicol. The invention is further directed to new oxazolidine derivatives useful in making Florfenicol and processes of making these derivatives. Examples of such intermediates include (4R,5R)-3-acetyl-2,2-dimethyl-4-hydroxymethyl-5-[4-(methylsulfonyl)phenyl]-1,3-oxazolidine; and (4S,5R)-3-acetyl-2,2-dimethyl-4-fluoromethyl-5-[4-(methylsulfonyl)phenyl]-1,3-oxazolidine.

REFERENCES:
patent: 2757209 (1956-07-01), Joris
patent: 2759927 (1956-08-01), Suter
patent: 2759970 (1956-08-01), Suter
patent: 2759971 (1956-08-01), Cutler
patent: 2759972 (1956-08-01), Suter
patent: 2759976 (1956-08-01), Suter
patent: 4235892 (1980-11-01), Nagabhushan
patent: 4311857 (1982-01-01), Nagabhushan
patent: 4361557 (1982-11-01), Nagabhushan
patent: 4582918 (1986-04-01), Nagabhushan
patent: 4677214 (1987-06-01), Nagabhushan
patent: 4743700 (1988-05-01), Jommi et al.
patent: 4876352 (1989-10-01), Schumacher et al.
patent: 4973750 (1990-11-01), Nagabhushan
patent: 5082863 (1992-01-01), Apelian et al.
patent: 5105009 (1992-04-01), Jommi et al.
patent: 5153328 (1992-10-01), Jommi et al.
patent: 5202484 (1993-04-01), Villa et al.
patent: 5227494 (1993-07-01), Schumacher et al.
patent: 5243056 (1993-09-01), Jommi et al.
patent: 5284966 (1994-02-01), Villa et al.
patent: 5332835 (1994-07-01), Jommi et al.
patent: 5336664 (1994-08-01), Camaggi et al.
patent: 5352832 (1994-10-01), Wu et al.
patent: 5382673 (1995-01-01), Clark et al.
patent: 5401852 (1995-03-01), Villa et al.
patent: 5556829 (1996-09-01), Camaggi et al.
patent: 5567844 (1996-10-01), Jommi et al.
patent: 5663361 (1997-09-01), Towson et al.
patent: 5789599 (1998-08-01), Davis et al.
patent: 5908937 (1999-06-01), Jommi et al.
patent: 1326926 (2001-12-01), None
patent: 0 014 437 (1983-02-01), None
patent: 0 130 633 (1985-01-01), None
patent: 0 200 739 (1989-07-01), None
patent: 0 423 705 (1991-04-01), None
patent: 0 454 067 (1991-04-01), None
patent: 500 177 (1992-08-01), None
patent: 0 423 705 (1995-01-01), None
patent: 0 130 633 (1996-09-01), None
patent: 500 177 (1999-01-01), None
patent: 745900 (1956-03-01), None
patent: 746015 (1956-03-01), None
patent: 746016 (1956-03-01), None
patent: WO 86/01799 (1986-03-01), None
patent: WO 90/02739 (1990-03-01), None
patent: WO 92/07824 (1992-05-01), None
patent: WO 94/14764 (1994-07-01), None
patent: WO 95/30672 (1995-11-01), None
patent: WO 2003/093221 (2003-11-01), None
Clark, J. E., “An Enzymatic Route to Florfenicol,”Synthesis, pp. 891-894, Oct. 1991.
Jommi, G. et al., “2-Oxazolidinones as regioselective protection of β-amino alcohols in the synthesis of 2-amino-1-aryl-3-fluoro-1-propanols,”Gazzetta Chemica Italiiana, vol. 116, pp. 485-489 (1986).
Jommi, G. et al., “Preparation of 2-[4-methlysulfonyl)phenyl]-2,3, Dihydrooxazolo [2,3-α] Isoindol-5(9bH)-One Derivatives and a New Synthesis of Thiamphenicol Analogs,”Gazzetta Chemica Italiiana, vol. 115, pp. 653-658 (1985).
Schumacher, D. et al., “An efficient synthesis of florfenicol,”J Org Chem., vol. 55, pp. 5291-5294 (1990).
Tyson, R., “Custom Synthesis and Process Development,”Chem. Ind.,vol. 4, pp. 118-122 (1990).

Affiliated with

Also associated with

Rating

Process for preparing florfenicol does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for preparing florfenicol, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for preparing florfenicol will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3645013