Process for preparing fast dispersing solid oral dosage form

Details Process for preparing fast dispersing solid oral dosage form Process for preparing fast dispersing solid oral dosage form

1997-07-11

1999-11-02

Dees, Jose' G.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

424400, 424451, 424455, 424456, 424457, 424458, 424459, 424460, 424461, 424484, 424485, 424486, 424487, 424488, 424489, A61K 914

Patent

active

059765771

ABSTRACT:
Process is provided for preparing an oral solid rapidly disintegrating freeze-dried dosage form of a pharmaceutically active substance having an unacceptable taste, wherein prior to freeze drying, a suspension of uncoated or coated coarse particles of a pharmaceutically active substance in a carrier material is cooled to reduce the viscosity and minimize release of the active substance during processing, as well as beyond the point of disintegration of the form in the mouth, to minimize bad taste from the drug.

REFERENCES:
patent: 5330763 (1994-07-01), Gole et al.
patent: 5670490 (1997-09-01), Whistler

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