Process for preparing examethylenecephem compounds

Details Process for preparing examethylenecephem compounds Process for preparing examethylenecephem compounds

1993-10-14

1995-11-28

Rizzo, Nicholas

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

540215, C07D50104, A61K 31545

Patent

active

054709725

ABSTRACT:
The object of the invention is to provide a .beta.-lactam compound and a 2-substituted methyl-3-cephem compound, both of which are of value as intermediates for the synthesis of cephem antibiotics.
The .beta.-lactam compound of the invention may be represented by the general formula ##STR1## wherein R.sup.1 represents a protected amino group, for instance; R.sup.2 represents hydrogen for instance; R.sup.3 represents hydrogen or a carboxy-protecting group; R.sup.4 represents an aryl group which may be substituted; R.sup.5 represents an alkenyl group which may be substituted, for instance. The 2-substituted methyl-3-cephem compound of the invention may be represented by the general formula ##STR2## wherein R.sup.1, R.sup.2 and R.sup.3 are as defined above; R.sup.6 represents an aryl group which may be substituted.

REFERENCES:
patent: 4463172 (1984-07-01), Horii et al.
patent: 4798890 (1989-01-01), Torii et al.
patent: 5077286 (1991-12-01), Bissolino et al.
patent: 5132301 (1992-07-01), Doherty et al.
patent: 5162521 (1992-11-01), Farina et al.

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