Process for preparing ethyl ester of L-DOPA

Details Process for preparing ethyl ester of L-DOPA Process for preparing ethyl ester of L-DOPA

1992-12-24

1994-10-11

Cintins, Marianne M.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

514567, 514649, 562433, 562445, 560 45, C07C22900, A61K 31195, A61K 31135

Patent

active

053548850

ABSTRACT:
A composition which comprises a pharmaceutically acceptable carrier and an active ingredient, such active ingredient comprising L-DOPA ethyl ester in an amount which is at least 97%, by weight, of the active ingredient, and L-DOPA in an amount which is less than 1% by weight of such active ingredient is provided by this invention. This invention also provides a process for preparing such a composition. Further, this invention provides a method of treating a patient suffering from Parkinson's disease which comprises administering to a patient a pharmaceutical composition comprising a therapeutically effective amount of L-DOPA ethyl ester and a pharmaceutically acceptable carrier.

REFERENCES:
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patent: 4035507 (1977-07-01), Bodor et al.
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patent: 4826875 (1989-05-01), Chiesi
patent: 4916151 (1990-04-01), Bey et al.
Cooper, D. R., et al. Clin. Neuropharmacol. 7: 89-98 (1984).
Fix, J. A., et al., Pharm. Res. 6:501-505 (1989).
Juncos, J. L., et al., Neurology 37:1242-1245 (1987).
Lai, C. M., et al., J. Pharm. Sci. 62:510-511 (1973).
Cooper et al, L-Dopa ester as potential prodrugs: . . . "disease". Journal f Pharmacy and Pharmacology, vol. 39(8) Aug. 1987.

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