Process for preparing erythromycin compound

Details Process for preparing erythromycin compound Process for preparing erythromycin compound

2005-07-12

2005-07-12

Wilson, James O. (Department: 1623)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

C514S025000, C536S007200, C536S004100, C536S018500

Reexamination Certificate

active

06916792

ABSTRACT:
The present invention is to provide a process for producing a 2′-O-acetyl-4″-formyl-8,9-anhydroerythromycin A 6,9-hemiketal compound 4, and it provide a process for producing an erythromycin compound which comprises reacting a formylating agent with a 2′-O-acetylerythromycin A compound 2 to obtain 2-′-O-acetyl-4″-O-formylerythromycin A compound 3, then, acting an acid on Compound 3 to subject to hemiketalation, and then adding an aqueous basic solution in an aqueous solution to precipitate Compound 4 as free crystals.

REFERENCES:
patent: 5959088 (1999-09-01), Miura et al.
patent: 0 846 697 (1998-06-01), None
patent: 846697 (1998-06-01), None
patent: 0 884 322 (1998-12-01), None
patent: 2-196796 (1990-08-01), None
New Current, vol. 7, No. 13, pp. 19-21 (Jun. 10, 1996).

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