Process for preparing erythromycin A oxime or a salt thereof

Details Process for preparing erythromycin A oxime or a salt thereof Process for preparing erythromycin A oxime or a salt thereof

1989-05-12

1993-12-28

Brown, Johnnie R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 72, 536 185, C07H 100

Patent

active

052740854

ABSTRACT:
A process for preparing erythromycin A oxime or a salt thereof which comprises reacting erythromycin A with hydroxylamine using an acid, is disclosed. Erythromycin A oxime and the salts thereof are useful as intermediates for the synthesis of macrolide antibiotics.

REFERENCES:
patent: 4349545 (1982-09-01), Gouin d'Ambrieres et al.
patent: 4526889 (1985-07-01), Bright
patent: 4672109 (1987-06-01), Watanabe et al.
Tetrahedron Letters, No. 2, Jan. 1970, pp. 157-160, Pergamon Press.
R. W. Alder et al.: "Mechanism in Organic Chemistry", 1971, pp. 321-322.
P. Sykes: "A Guidebook to Mechanism in Organic Chemistry", edition 5, 1981, pp. 215-217.
Morrison et al. Organic Chemistry, Third Edition, published by Allyn and Bacon, Inc. (1979) p. 640.

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