Process for preparing erianin

Details Process for preparing erianin Process for preparing erianin

2011-03-01

2011-03-01

Keys, Rosalynd (Department: 1621)

Organic compounds -- part of the class 532-570 series

Organic compounds

Oxygen containing

C568S013000, C568S016000, C568S017000, C568S315000, C568S316000

Reexamination Certificate

active

07897820

ABSTRACT:
A process for preparing Erianin (Dihydro Combretastation A-4), wherein 3,4,5-trimethoxy benzaldehyde is converted to phosphonium salt or phosphonate ester or the likes thereof, then reacted with isovanillin (3-hydroxyl-4-methoxyl benzaldehyde) including a protected hydroxyl in the 3-position, followed by hydrogenation and deprotection.

REFERENCES:
patent: 5430062 (1995-07-01), Cushman et al.
patent: 6759555 (2004-07-01), Mutti et al.
patent: 1660745 (2005-08-01), None
patent: 1704393 (2005-12-01), None
Machine generated translation of CN 1704393, published Dec. 2005.
Getahun, Z. et al., “Synthesis of alkoxy-substituted diaryl compounds and correlation of ring separation with inhibition of tubulin polymerization: differential enhancement of inhibitory effects under suboptimal polymerization reaction conditions”, Journal of Medical Chemistry, 35(6); 1992, pp. 1058-1067.

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