Process for preparing enantiomerically pure 6-{4-chlorophenyl) (

Details Process for preparing enantiomerically pure 6-{4-chlorophenyl) ( Process for preparing enantiomerically pure 6-{4-chlorophenyl) (

1997-03-28

1998-05-05

Morris, Patricia L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D24918

Patent

active

057468400

ABSTRACT:
1,2,4-triazol-1-yl)methyl!-1-methyl-1H-benzotriazole comprising the resolution of (.+-.)-6-!(4-chlorophenyl)-hydrazinomethyl)-1-methyl-1H-benzotriazole and converting the appropriate enantiomerically pure hydrazine intermediate 1,2,4-triazol-1-yl)methyl!-1-methyl-1H-benzotriazole.

REFERENCES:
patent: 4943574 (1990-07-01), Raeymaekers et al.
patent: 5663354 (1997-09-01), Willemsens et al.
R7613 and Enantiomers: Selective, Nonsteroidal Inhibitors of the Cytochrome P450-Dependent Oestrogen Synthesis, Biochemical Pharmacology, vol. 40, No. 8, pp. 1707-1718, 1990.
Comparative Effects of the Aromatase Inhibitor R76713 and of its Enantiomers R83839 and R83842 on Steroid Biosynthesis In Vitro and In Vivo, J. Steroid Biochem. Molec. Biol. vol. 37, No. 6, pp. 1049-1054.

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