Process for preparing EDTA-free heparins, heparin fractions and

Details Process for preparing EDTA-free heparins, heparin fractions and Process for preparing EDTA-free heparins, heparin fractions and

1990-09-24

1992-05-05

Robinson, Douglas W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

514 56, A61K 31725, C08B 3710

Patent

active

051109182

ABSTRACT:
Heparins, heparin fractions or fragments, optionally salified with pharmaceutically acceptable cations, having molecular weight ranging from 1.000 to 30.000 D, characterized by an EDTA content lower than 0.1%, by the absence, in the .sup.1 H--NMR spectra, of the signals due to EDTA between 2.50 and 4.00 p.p.m. and substantially free from bleeding effect and optionally free from signals, in the .sup.13 C--NMR spectrum, from 80 to 86 ppm.

REFERENCES:
patent: 4652555 (1987-03-01), Goulay et al.
patent: 4692435 (1987-09-01), Lormeau et al.
Heparin--Past, Present and Future by Erwin Coyne, pp. 10-17, copyright 1981 by Elsevier North Holland, Inc.
The United States Pharmacopeia, Jan. 1985, pp. 480-483.
British Pharmacopoeia, 1988, pp. 282-283.
Pharmacopee Europeenne, 1984, pp. 332 through 332-4, 333 through 333-5.

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