Process for preparing e

Details Process for preparing e Process for preparing e

1996-12-30

1998-05-26

Bond, Robert T.

Organic compounds -- part of the class 532-570 series

Organic compounds

Unsubstituted hydrocarbyl chain between the ring and the -c-...

514183, 564 82, 564209, C07D25900, A61K 31395

Patent

active

057567280

ABSTRACT:
An improved process for preparing comprising the selective functionalization of an acyclic tetraamine, and subsequent dimerization and hydrolyzation/tosylation to obtain a 1,4-phenylenebis-methylene bridged hexatosyl acyclic precursor in a first step, the cyclization of said precursor to obtain a hexatosyl cyclam dimer in a second step, and the detosylation of said cyclam dimer in a third step followed by basification to obtain the desired

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Bridger et al, Journal of Medicinal Chemistry, vol. 38, No. 2, pp. 366-378 (Jan. 20, 1995).
Chemical Abstracts, vol. 107, No. 18, Abstract No. 167695 (Nov. 2, 1987).
Brandes et al, Bulletin de la Societe Chimique de France, vol. 133, No. 1, pp. 65-73 (1996).
J. Med. Chem., vol. 38, No. 2, pp. 366-378 (1995).

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