Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing compound containing saccharide radical
Patent
1997-07-28
1999-09-21
Railey, II, Johnny F.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Preparing compound containing saccharide radical
4352523, 43525235, 4353201, C12P 1956, C12N 121, C12N 1563, C12N 1576
Patent
active
059553197
ABSTRACT:
The present invention concerns a process for improving doxorubicin production by means of a recombinant Streptomyces peucetius strain bearing a mutation in the gene dnrU coding for a protein involved in the metabolism of daunorubicin.
REFERENCES:
Stutzman-Engwall et al., Proc. Natl. Acad. Sci. USA 86:3135-3139 (1989).
Otten et al., J. Bacteriol. 172(6):3427-3434 (1990).
Dickens et al., J. Bacteriol. 178(11):3389-3395 (1996).
Scotti et al., J. Bacteriol. 178(24):7316-7321 (1990).
Breme Umberto
Colombo Anna Luisa
Filippini Silvia
Fonstein Leonid
Hutchinson Charles R.
Pharmacia & Upjohn S.p.A.
Railey II Johnny F.
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