Process for preparing distamycin derivatives

Details Process for preparing distamycin derivatives Process for preparing distamycin derivatives

2005-10-04

2005-10-04

Campell, Bruce R. (Department: 1654)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C548S530000

Reexamination Certificate

active

06951951

ABSTRACT:
A process for preparing distamycin derivatives possessing antitumor activity, by starting from distamycin A itself, is described. The process involves the preparation of the novel intermediates of formula (III)

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Cytotoxic α-Bromoacrylic Derivatives of Distamycin Analogues Modified at the Amidino Moiety P. Cozzi, et al. (2000) Bioorg. Med. Chem. Letters, 10(11) pp. 1273-1276.

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