Process for preparing dipeptides

Details Process for preparing dipeptides Process for preparing dipeptides

1992-12-15

1995-05-23

Kumar, Shailendra

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Enzymatic production of a protein or polypeptide

435711, 435712, 435212, 435219, 435220, 435839, C12P 2100

Patent

active

054181461

ABSTRACT:
This invention relates to an improvement in a method for manufacturing dipeptides by coupling N-blocked aspartic acid and a phenylalanine lower alkyl ester in a medium containing a water-miscible organic solvent mixture in the presence of an immobilized metallo-protease so that a continuous reaction is established with stable enzyme activity.

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patent: 4284721 (1981-08-01), Oyama et al.
patent: 4339534 (1982-07-01), Johansen
patent: 4521514 (1985-06-01), Oyama et al.
patent: 4935355 (1990-06-01), Ulmer et al.
patent: 5002872 (1991-03-01), Gross
J. Org. Chem., 46, 5241-5242 (1981).
Biochem. 17(24), 5220 (1978).

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