Process for preparing dioxolenone derivatives used for making pr

Details Process for preparing dioxolenone derivatives used for making pr Process for preparing dioxolenone derivatives used for making pr

1995-04-03

1997-03-11

Marquis, Melvyn I.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

549229, 560 56, 560174, 562463, 562577, C07D32100

Patent

active

056103140

ABSTRACT:
A process is provided for preparing dioxolenone derivatives of the structure ##STR1## wherein R is alkyl or aryl and R.sub.3 is CO.sub.2 R.sub.2 (where R.sub.2 is alkyl or arylalkyl such as benzyl, diphenylmethyl or para-methoxybenzyl). Intermediates produced in the above process are also provided as well as a method for preparing squalene synthetase inhibitors employing such intermediates.

REFERENCES:
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Saari, W. S. et al, "3-Hydroxy-.alpha.-methyltyrosine Progenitors: Synthesis and evaluation of Some (2-Oxo-1,3-dioxol-4-yl)methyl Esters", J. Med. Chem. 27, 713-717, (1984).
Alpegiani, M. et al, "On the Preparation of 4-Hydroxymethyl-5-Methyl-1,3-Dioxol-2-One", Synthetic Communications, vol. 22(9), 1277-1282 (1992).
Fischer, H. J. et al, "Darstellung Einiger Dialkylsubstituierter Cycloaddition an Athylen", Tetrahedron Letters No. 17, pp. 1701-1704 (1972).
Stahlke, K.-R. et al, "Zur Photochemie ary-substituierter Vinylencarbonate" Liebigs Ann. Chem. 764, 116-124 (1972).

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