Process for preparing diltiazem using a heterogeneous...

Details Process for preparing diltiazem using a heterogeneous... Process for preparing diltiazem using a heterogeneous...

2005-04-19

2005-04-19

Solola, Taofiq (Department: 1626)

Organic compounds -- part of the class 532-570 series

Organic compounds

Unsubstituted hydrocarbyl chain between the ring and the -c-...

Reexamination Certificate

active

06881839

ABSTRACT:
The present invention comprises a simplified synthesis of (+)-diltiazem through IE-PdOsW wherein IE is ion-exchanger, catalyzed three-component coupling reaction and Fe3+-exchanged clay catalyzed ring opening of sulfite with 2-aminothiophenol followed by cyclization as key steps.

REFERENCES:
Lohray et al, “Anchimeric Assisted Unprecedented Sni-type Cleavage of Cyclic Sulfite: Application in the Synthesis of The Calcium Channel Blocker Diltiazem”, J. Org. Chem., vol. 60, 1995, pp. 5983-5985, XP002251356.
Choudary, “A Trifunctional Catalyst For the Synthesis of Chiral Diols”, Angewandte, Chemie, International Edition, Verlag Chemie, Weinheim, DE, vol. 40, No. 24, Dec. 17, 2001, pp. 4620-4623, XP00111177, ISSN: 0570-0833.

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