Process for preparing dibenzothiazepine derivatives

Details Process for preparing dibenzothiazepine derivatives Process for preparing dibenzothiazepine derivatives

2008-01-01

2008-01-01

Coleman, Brenda (Department: 1624)

Organic compounds -- part of the class 532-570 series

Organic compounds

Unsubstituted hydrocarbyl chain between the ring and the -c-...

Reexamination Certificate

active

11392577

ABSTRACT:
A process for preparing a dibenzothiazepine derivative such as dibenzo[b,f][1,4]thiazepin-11-one employable as a starting material for the preparation of 11-[4-(2-(2-hydroxyethoxy)ethyl)]-1-piperadinyldibenzothiazepine derivative which is known to be effective as an antipsychotic pharmaceutical, has the steps of reacting a nitrobenzene derivative with a thiosalicylic acid derivative, reducing the obtained 2-nitro-2′-carboxy-diphenylsulfide derivative, and subjecting the obtained 2-amino-2′-carboxy-diphenylsulfide derivative to dehydration-condensation reaction.

REFERENCES:
patent: 11-199574 (1999-07-01), None
patent: WO 92-19607 (1992-11-01), None
Bennett et al., Synthesis of 2-Methoxydibenzo[b,f](1,4)-Thiazepin-11(10H)-one-5,5-dioxide, Organic Preparations and Procedures Int., vol. 6, No. 6, pp. 287-293 (1974).
Kuti et al., Novel Reactions of Spirosulfurane Precursor Sulfides and Sulfoxides, Phosphorus, Sulfur, and Silicon, vol. 85, pp. 119-127 (1993).
International Search Report, Application No. PCT/JP99/03719, Mailing Date: Oct. 19, 1999.
J. Heterocycl. Chem. 1975, 12(6), pp. 1211-1213.
Allen et al., 8-Carboxy-6-sulfamyldibenz(b,f)[1,4]oxazepines and -thiazepines as Potential High-Ceiling Diuretics, Journal of Medicinal Chemistry, vol. 21, No. 8, pp. 838-840, 1978.

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