Process for preparing dialkyl (p-aminobenzoyl) glutamates

Details Process for preparing dialkyl (p-aminobenzoyl) glutamates Process for preparing dialkyl (p-aminobenzoyl) glutamates

1978-02-03

1979-01-23

Thomas, Jr., James O.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

560 41, 544260, C07F 306, C07C10126

Patent

active

041361016

ABSTRACT:
A process for the preparation of dialkyl (p-aminobenzoyl) glutamates is disclosed. Dialkyl (p-Aminobenzoyl) glutamates are useful as intermediates in the synthesis of N-{p-([(2,4-diamino-6-pteridinyl)-methyl]methylamino)benzoyl} glutamic acid, also known as 4-amino-N.sup.10 -methylpteroylglutamic acid. The compound zinc N-(p-methylaminobenzoyl)-L-(+)-glutamate, is also disclosed.

REFERENCES:
patent: 3892801 (1975-07-01), Kazan
Lee et al., J. of Medicinal Chem., vol. 17, No. 3, pp. 326-329 (1974).

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