Process for preparing di-C.sub.1 - C.sub.4 -alkyl 5-nitro-isopht

Details Process for preparing di-C.sub.1 - C.sub.4 -alkyl 5-nitro-isopht Process for preparing di-C.sub.1 - C.sub.4 -alkyl 5-nitro-isopht

1998-05-06

1999-12-14

Barts, Samuel

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

C07C20500

Patent

active

060020415

ABSTRACT:
Particularly pure di-C.sub.1 -C.sub.4 -alkyl 5-nitro-isophthalates are obtained in good yield and in a simple process by dissolving 5-nitro-isophthalic acid in a mixture of a C.sub.1 -C.sub.4 -alkyl alcohol and a solvent which is miscible or only partially miscible with water, heating in the presence of a strong acid, thus forming a second, aqueous phase, crystallizing out, after the esterification reaction has ended, the di-C.sub.1 -C.sub.4 -alkyl 5-nitro-isophthalate formed from the organic phase by cooling and removing the aqueous phase before or after the di-C.sub.1 -C.sub.4 -alkyl 5-nitro-isophthalate is separated off.

REFERENCES:
patent: 2680730 (1954-06-01), Martin
patent: 5744628 (1998-04-01), Pfirmann et al.
Laboratory technique in organic chemistry, pp. 195-196, in paricular paragraphs 166-168, 1938.
Clinton, R. O. and S.C. Laskowski. (Sep. 1948) "The Preparation of Methyl Esters" Journal of the American Chemical Society, vol. 70, No. 9, pp. 3135-3136; published in US.
Hiroshi, Takimoto. (Jan. 28, 1985) "Production of P-Nitrobenzoic Acid Ester" Patent Abstracts of Japan, European Patent Office, vol. 9, No. 130, one page, published in EPO.
Wohl, A. (1910). "Uber Estersauren un Amidsaurenden Isophthalsaure-Reihe, ein Beitrag zur Frage der Gleichwertigkelt der Stellungen 2 und 6 am Benzolkern." Ber., vol. 43, pp. 3474-3489, published in Germany. In German.
Wohl, A. (1910). "Uber Estersauren der Isophthalsaure-Reihe, ein Beitrag zur Frage der Gleichwertigkelt der Stellungen 2 und 6 am Benzolkern." Ber., vol. 43, pp. 3474-3481. In German.
Clendinning, R. A., and W. H. Rauscher. (Aug. 1961). "Synthesis of Some Substituted Alkyl Derivatives of Phthalic and Isophthalic Acids." Journal of Organic Chemistry. vol. 26, pp. 2963-2965.
Cassebaum, H. and K. Dierbach. (1996). "Dunnflussige trijodierte Rontgenkontrastmittel fur die Angiographie." Pharmasie. vol. 21(3), pp. 167-170. In German.
Singh, G.B. and H.G.S. Rathore. (Nov./Dec. 1980). "Study on Radiopaque Iothalamic Acid-A comparative evaluation of its synthesis. " Indian Drugs & Pharmaceutical Industry. pp. 35-38, 38A and 38B.

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