Chemistry: analytical and immunological testing – Tracers or tags
Patent
1996-11-06
1998-11-03
Snay, Jeffrey
Chemistry: analytical and immunological testing
Tracers or tags
G01N 3700
Patent
active
058307630
ABSTRACT:
A process for the preparation of organic and inorganic deuterium-tagged compounds is disclosed. The process comprises heating a deuterium oxide-solution of an organic or inorganic compound, the solution having a pH of from about 10 to about 1 to a temperature and pressure so that a supercritical reaction mass forms and one or more deuterium atoms of the deuterium oxide solvent exchanges with one or more protons of the organic or inorganic compound. After cooling the reaction solution formed from the supercritical reaction, the organic or inorganic deuterium-tagged compound is separated.
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patent: 5665538 (1997-09-01), Slater et al.
patent: 5710046 (1998-01-01), Rutledge et al.
Yao, J. et al "Deuteration of Extremely Weak Organic Acids by Enahnced Acid-Base Reactivity in Supercritical Deuteroxide Solution" J. Am. Chem. Soc. vol. 116, pp. 11229-11233, 1994.
Werstiuk, N.H. et al "The Hight Temperature and Dilute Acid (HTDA) Procedure as a General Method of Replacing Aromatic Hydrogen by Deuterium" Can. J. Chem. vol. 52, pp. 2169-2171, 1974.
Junk, T.H. et al. "Preparative Supercritical Deuterium Exchange in Arenes and Heteroarenes" Tetrahedron Letters, vol. 37, No. 20, pp. 3445-3448, May 13, 1996.
Catallo W. James
Junk Thomas
Hammond Richard J.
Snay Jeffrey
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