Process for preparing desacetoxycephalosporanic acid

Details Process for preparing desacetoxycephalosporanic acid Process for preparing desacetoxycephalosporanic acid

1981-06-29

1982-08-24

Coughlan, Jr., Paul M.

Organic compounds -- part of the class 532-570 series

Organic compounds

Chalcogen in the nitrogen containing substituent

544 30, C07D50104

Patent

active

043462197

ABSTRACT:
Process for preparing 7-ADCA and 7-(N,N-disubstituted)aminodesacetoxycephalosporins which comprises reacting 7-ACA or an N,N-disubstituted derivative thereof with a tri-(C.sub.1 -C.sub.6 alkyl)silane in a highly acidic organic acid, e.g. trifluoroacetic acid, with a Lewis acid, preferably boron trifluoride, at a temperature of 20.degree. C. to 100.degree. C. E.g., 7-ADCA is readily prepared in high yield, is purified by isoelectric precipitation, and is useful for preparing cephalexin.

REFERENCES:
patent: 3134774 (1964-05-01), Chow et al.
patent: 3773761 (1973-11-01), Blackburn et al.
patent: 3929775 (1975-12-01), Ochiai et al.
patent: 3991051 (1976-11-01), Breuer et al.
patent: 4051131 (1977-09-01), Robinson
Aries, Chemical Abstracts, 84P121874f (1976).

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