Process for preparing derivatives of baccatine III and of 10-dea

Details Process for preparing derivatives of baccatine III and of 10-dea Process for preparing derivatives of baccatine III and of 10-dea

1989-04-03

1990-05-08

Hollrah, Glennon H.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

549511, C07D30514

Patent

active

049240129

ABSTRACT:
Process for preparing derivatives of baccatine III and of 10-deacetylbaccatine III, of general formula (I), in which R is hydrogen or acetyl, by condensation of an acid of general formula (II) with a derivative of baccatine III or of 10-deacetylbaccatine III of general formula (III), R.sub.1, R.sub.2 and R.sub.3 denoting hydroxy-protecting groups, followed by the replacement of the protecting groups by hydrogen. ##STR1##

REFERENCES:
patent: 4814470 (1989-03-01), Colin et al.
patent: 4857653 (1989-08-01), Colin et al.
Gueritte-Voegelein et al., J. Natural Products, 50(1), pp. 9-18, 1987.
Lataste et al., Proc. Nat'l. Acad. Sci. USA, 81, pp. 4090-4094, Jul. 1984.

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