Process for preparing daunorubicin

Details Process for preparing daunorubicin Process for preparing daunorubicin

1992-10-09

1994-11-15

Low, Christopher S. F.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Transferase other than ribonuclease

435886, 435888, 536 232, 930240, 935 14, C12N 910

Patent

active

053647815

ABSTRACT:
The ability to convert carminomycin to daunorubicin can be conferred on a host by transforming the host with a recombinant vector comprising a DNA having the configuration of restriction sites shown in FIGS. 2, 3 & 4 and nucleotide sequence shown in FIG. 3 of the accompanying drawings or a restriction fragment derived therefrom containing a gene coding for carminomycin 4-O-methyltransferase.

REFERENCES:
Bradshaw et al. (eds.) 1990, in: Proteins: Form and Function, Elsevier Trends J. Cambridge. (Elsevier Sci. Publ.) pp. 1-19.
Connors et al. 1990, J. Gen. Microbiol., 136, 1895-1898.

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