Process for preparing daunorubicin

Details Process for preparing daunorubicin Process for preparing daunorubicin

1996-06-10

1997-07-29

Guzo, David

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing compound containing saccharide radical

43525235, 4353201, 536 237, C12P 1956, C12N 119, C12N 1509, C07H 2104

Patent

active

056521251

ABSTRACT:
The ability to improve the conversion of .epsilon.-rhodomycinone to daunorubicin can be conferred on a bacterial host transformed with a recombinant vector comprising a DNA coding for an appropriate protein useful for that conversion. Furthermore, the bacterial host may have a mutation that blocks the function of a gene of daunorubicin metabolism.

REFERENCES:
patent: 5364781 (1994-11-01), Hutchinson et al.
Ye et al., Isolation and sequence analysis of polyketide synthase genes from the daunomycin-producing Streptomyces spp. strain C5. J. Bacteriol. vol. 176(20):6270-6280 Oct. 31, 1994.
Silvia Filippini, et al.; Streptomyces peucetius daunorubicin biosynthesis gene, dnrF:sequence and heterologous expression; Microbiology (1995), 141, 1007-1016.
Ann Grimm, et al.; Characterization of the Streptomyces peucetius ATCC 29050 genes encoding doxorubicin polyketide synthase; Gene 151 (1994) 1-10.
Mark A. Gallo, et al.; The dnrM gene in Streptomyces peucetius contains a naturally occurring frameshift mutation that is suppressed by another locus outside of the daunorubicin-production gene cluster; Microbiology (1996), 142, 269-275.
Krishnamurthy Madduri, et al.; Functional Characterization and Transcriptional Analysis of a Gene Cluster Governing Early and Late Steps in Daunorubicin Biosynthesis in Streptomyces peucetius; Journal of Bacteriology Jul. 1995, 177 pp.. 3879-3884.
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Kim J. Stutzman-Engwall, et al.; Regulation of Secondary Metabolism in Streptomyces spp. and Overproduction of Daunorubicin in Streptomyces peucetius; Journal of Bacteriology, Jan. 1992, 174 pp. 144-154.
Krishnamurthy Madduri, et al.; Functional Characterization and Transcriptional Analysis of the dnrR.sub.1 Locus, Which Controls Daunorubicin Biosynthesis in Streptomyces peucetius; Journal of Bacteriology, Mar. 1995, 177 pp. 1208-1215.
Sharee L. Otten, et al.; Regulation of Daunorubicin Production in Streptomyces peucetius by the dnrR.sub.2 Locus; Journal of Bacteriology, Mar. 1995, 177 pp. 1216-1224.
Michael L. Dickens, et al.; Cloning, Sequencing, and Analysis of Aklaviketone Reductase from Streptomyces sp. Strain C5; Journal of Bacteriology, Jun. 1996, 178 pp. 3384-3388.
Sharee L. Otten, et al.; Cloning and Characterization of the Streptomyces peucetius dnrQS Genes Ecoding a Daunosamine Biosynthesis Enzyme and a Glycosyl Transferase Involved in Daunoribicin Biosynthesis; Journal of Bacteriology, No. 1995, 177 pp. 6688-6692.

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