Chemistry: molecular biology and microbiology – Micro-organism – per se ; compositions thereof; proces of... – Bacteria or actinomycetales; media therefor
Patent
1994-06-15
1996-10-08
Low, Christopher S. F.
Chemistry: molecular biology and microbiology
Micro-organism, per se ; compositions thereof; proces of...
Bacteria or actinomycetales; media therefor
43525233, 43525235, 4351723, 4353201, 435193, 435 691, 536 232, 536 237, 536 231, C12N 121, C12N 910, C12N 1570
Patent
active
055630642
ABSTRACT:
The ability to convert carminomycin to daunorubicin can be conferred on a host by transforming the host with a recombinant vector comprising a DNA having the configuration of restriction sites shown in FIGS. 2, 3 and 4 and a nucleotide sequence shown in FIG. 3 of the accompanying drawings or a restriction fragment derived therefrom containing a gene coding for carminomycin 4-O-methyltransferase.
REFERENCES:
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Watson et al., 1987, in: Molecular Biology Of The Gene, Fourth Edition, Benjamin/Cummings Publishing Co., Menlo Park, CA, p. 313.
Connors et al., 1990, "Biosynthesis of anthracyclines: carminomycin 4-O-methyltransferase, the terminal enzymic step in the formation of daunomycin" J. Gen. Microbiol., 136, 1895-1898.
Bradshaw et al. (eds.), 1990, in: Proteins: Form and Function, Elsevier Trends J. Cambridge. (Elsevier Sci. Publ.) pp. 1-19.
Connors et al., 1993, "Partial purification and properties of carminomycin 4-O-thyltransferace from Steptomycessp. strain C5 J. Gen Microbiol"., 139, 1353-1362.
Colombo Anna L.
Hutchinson Charles R.
Madduri Krishna M.
Torti Francesca
Farmitalia Carlo Erba S.r.l.
Low Christopher S. F.
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