Process for preparing D-homo oxasteroids

Details Process for preparing D-homo oxasteroids Process for preparing D-homo oxasteroids

1978-06-15

1979-05-22

Chan, Nicky

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

C07D31102

Patent

active

041559177

ABSTRACT:
A steroid having the formula ##STR1## or the 1,2-dehydro derivative thereof, can be prepared by reacting the corresponding steroid having the formula ##STR2## or the 1,2-dehydro derivative thereof, with ozone and an alkanol having the formula R.sub.3 --OH and then treating the reaction mixture with a reducing agent; wherein R'.sub.1 is hydrogen, acyloxy or halogen; R.sub.3 is alkyl; R.sub.4 is carbonyl, .beta.-hydroxymethylene, .beta.-chloromethylene or .beta.-bromomethylene; R.sub.5 is hydrogen, fluorine, chlorine or bromine; R.sub.6 is hydrogen, fluorine or methyl; and R.sub.7 is hydrogen, chlorine or bromine.

REFERENCES:
patent: 3257412 (1966-06-01), Baran
Kuo et al., J. Org. Chem., 28, 1619, (1963).
Iriarte et al., J.C.S. Chem. Comm., p. 1110, (1972).

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