Process for preparing d-2-(6-methoxy-2-naphthyl)-propionic acid

Details Process for preparing d-2-(6-methoxy-2-naphthyl)-propionic acid Process for preparing d-2-(6-methoxy-2-naphthyl)-propionic acid

1992-05-28

1993-01-12

Killos, Paul J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D26304

Patent

active

051792087

ABSTRACT:
A process for the prepaation of d-2-(6-methoxy-2-naphthyl)-propionic acid of formula (I) used as nonsteroid antipyretic analgesics, which comprises reacting oxazolidinone of formula (II) with 6-methoxy-2-naphthylacetchloride of formula (IV), methylizing [N-(y-methoxy-2-naphthyl)acetyl]-oxazolidinone of formula (N), and reacting[N-(2S)-2-(6-methoxy-2-naphthyl)-propionyl]-oxazolidinone of formula (VI) in alkali metal hydroxy, and intermediate compound obtained by the process, [N-(6-methoxy-2-naphthyl)acetyl]-oxazolidinone of formula (V) and [N-(2S)-2-(6-methoxy-2-naphthyl)-propionyl]-oxazolidinone (VI) ##STR1## wherein R.sup.1 is methyl, isopropyl, secondary-butyl, tert-butyl, benzyl, or phenyl group, and R.sup.2 is hydrogen or phenyl group.

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J. Am. Chem. Soc. 104 (1982) 1737.
J. Am. Chem. Soc. 73 (1951) 4199.

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