Process for preparing D-2-(6-methoxy-2-naphthyl)-propionic acid

Details Process for preparing D-2-(6-methoxy-2-naphthyl)-propionic acid Process for preparing D-2-(6-methoxy-2-naphthyl)-propionic acid

1991-01-25

1992-09-08

Killos, Paul J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

C07C 6206

Patent

active

051459930

ABSTRACT:
A process for the preparation d-2-(6-methoxy-2-naphthyl) propionic acid of formula (I) used as nonsteroid antipyretic analgesics, which comprises reacting oxazolidinone of formula (II) with 6-methoxy-2-naphthylacetchloride of formula (IV), methylizing [N-(6-methoxy-2-naphthyl)acetyl]-oxazolidinone of formula (V), and reacting [N-(2S)-2-(6-methoxy-2-naphthyl)-propionyl]-oxazolidinone of formula (VI) in alkali metal hydroxy, and intermediate compound obtained by the process, ]N-(6-methoxy-2-naphthyl)acetyl]-oxazolidionone of formula (V) and [N-(2S))-2-(6-methoxy-2-naphthyl)-propionyl]-oxazolidinone (VI).

REFERENCES:
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patent: 3652683 (1972-03-01), Harrison
patent: 3658858 (1972-04-01), Harrison
patent: 3658863 (1972-04-01), Harrison
patent: 3663584 (1972-05-01), Alvarez
patent: 3683015 (1972-08-01), Dyson
patent: 3686238 (1972-08-01), Zaffaroni
J. Am. Chem. Soc. 104(1982) 1737.
J. Am. Chem. Soc. 73(1951) 4199.

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