Process for preparing cyclic CIS-1-amino-2-alkanols

Details Process for preparing cyclic CIS-1-amino-2-alkanols Process for preparing cyclic CIS-1-amino-2-alkanols

1993-09-14

1996-05-14

Raymond, Richard L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

564 1, 564414, 564424, 564428, C07C20958

Patent

active

055169430

ABSTRACT:
A two-step process for the conversion of a trans-1-amino-2-hydroxycycloalkane stereoselectively to a cis-1-amino-2-hydroxycycloalkane is disclosed. The novel step, a one-step hydrolysis with formal inversion, can be used to convert an amide of a trans-1-amino-2-hydroxycycloalkane to a cis-1-amino-2-hydroxycycloalkane. Methods for obtaining the trans-1-amino-2-hydroxycycloalkanes and their amides from alkenes are also disclosed. A preferred process converts indene to cis-1-amino-2-indanol.

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