Process for preparing crystalline Form I of cabergoline

Details Process for preparing crystalline Form I of cabergoline Process for preparing crystalline Form I of cabergoline

2005-10-11

2005-10-11

Aulakh, Charanjit S. (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C546S067000, C546S061000, C514S288000

Reexamination Certificate

active

06953854

ABSTRACT:
A process for producing crystalline form I of cabergoline, which process comprises crystallization of the desired form from a toluene/diethyl ether mixture comprising raw cabergoline, followed by recovery and drying of the resulting crystals. A new solvate form V of cabergoline, useful as an intermediate, is also provided.

REFERENCES:
patent: 4526892 (1985-07-01), Salvati et al.
patent: 5382669 (1995-01-01), Candiani et al.
patent: 5705510 (1998-01-01), Desantis, Jr.
patent: 6727363 (2004-04-01), Tomasi et al.
patent: 2003/0144516 (2003-07-01), Candiani et al.
patent: 2003/0149067 (2003-08-01), Tomasi et al.
patent: 2003/0187013 (2003-10-01), Tomasi et al.
patent: 0040325 (1986-03-01), None
patent: 2103603 (1983-02-01), None
patent: WO 95/05176 (1995-02-01), None
patent: WO 99/36095 (1999-07-01), None
patent: WO 99/48484 (1999-09-01), None
patent: WO 01/70740 (2001-09-01), None
P. Sabatino et al, “X-ray Crystal Structure and Conformational Analysis of N-(3-diamethylaminopropyl)N-ethlaminocarbonyl-6-(2-propenyl)ergoline-8-beta-carboxamide (cabergoline)”, II Farmco, vol. 50—No. 3, pp. 175-178, 1995.
E. Brambilla et al, “Synthesis and Nidtion Activity of a New Class of Ergoline Derivative”, European Journal of Medicinal Chemistry, vol. 24, pp. 421-426, 1989.
International Search Report, 3 pages, (Aug. 2001).

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